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KMID : 0870519970010010121
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Journal of Korean Academy of Addiction Psychiatry
1997 Volume.1 No. 1 p.121 ~ p.132
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Allelic Frequency of Dopamine D2 Receptor(DRD2) Gene in Korean Male Alcohol Dependence
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이종섭:Lee Jong-Sub
오미희:Oh Mee-Hee/이창훈:Lee Chang-Hoon/송경순:Song Kyoung-Soon/배종훈:Bae Jong-Hoon/기선완:Ki Sun-Wan/이홍식:Lee Hong-Shick/유계준:Yoo Kae-Joon
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Abstract
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Dopamine D2 receptor(DRD2) gene is known to have a strong effect on susceptibility of alcohol dependence and to
play an important role on appetite such as alcohol seeking behavior. It is known that alcohol induces excitatory effects
on dopamine neurons and stimulates brain reward systems by which man craves euphorogenic reward effect of drug(such as alcohol). And it has been suggested that DRD2 has a direct role on alcohol seeking behavior.
This study investigated polymorphic patterns of DRD2 gene of Korean male alcohol dependence by restriction fragment
length polymorphism(RFLP) and associations of Korean character traits with susceptibility on alcohol. Also, this study
examined allelic association of DRD2 gene in various chara cteristics and alcohol-related of alcohol dependence.
Subjects of this study consisted of 71 patients with alcohol dependence and 139 healthy male subjects without alcohol
dependence for the study of allelic association of DRD2 gene in Korean male alcohol dependence. Allelic association of DRD2 gene between two groups was tested by chi-square test, and those in severity and family history of alcohol dependence, age onset of alcohol drinking, and duration of alcohol drinking history were tested by ANOVA and t-test.
The results were as followings；
1) A1A1, A1A2, A2A2 genotype frequency of DRD2 gene in Korean male alcohol dependence were 19.7%, 29.6%, 50.7%
and those of control group were 15.8%, 51.8%, 33.1%. There was statistically significant difference between two groups.
2) Ratios of Korean male alcohol dependence with and without A1 allele were 0.49, 0.51 respectively, and those of
control groups were 0.67, 0.33 respectively. The difference between two groups were statistically significant. But the difference between two groups on ratio of presence of A2 allele was not statistically insignificant.
3) A1 and A2 allelic frequencies of Korean male alcohol dependence were 0.35 and 0.65 and those of control group were
0.42, 0.58 respectively. So there was no evidence of DRD2 A1 allelic association in Korean alcohol dependence.
4) According to Diagnostic Criteria of National Council on Alcoholism(NCA) on severity alcohol dependence, the genotype
of the most severe alcohol dependence was A1A1. on the other hand, the less severe type was A1A2, and the least severe
type was A2A2. And A1 and A2 allele frequency of severe alcohol dependence were 0.46 and 0.54 respectively and those of less severe alcohol dependence were 0.18 and 0.72 respectively. Therefore, there was allelic association of DRD2 gene in severity of Korean male alcohol dependence.
5) There were statistically significant differences among subgroups with A1A1, A1A2, A2A2 genotypes on scores of NCA
in total patients with alcohol dependence and also significant differences between patients with alcohol dependence with
and without A1 allele on scores of NCA. Therefore, there was statistically significant possibility in allelic association of DRD2 gene in NCA scores of patients with alcohol dependence.
6) There were no allelic associations of DRD2 gene in the variable characteristics(age, family history of alcohol dependence, onset age of alcohol drinking, and onset age of alcohol problems).
7) In comparing A1 allelic frequencies of DRD2 gene in this study with those in other studies on various populations, there
were no differences statistically among Asians in controls and statistically significant differences, however, in other populations elsewhere. And there were also higher in A1 allelic frequencies in Korean and Japanese with alcohol dependence than the whites. In summarizing above results, there was no allelic association of DRD2 gene in Korean male alcohol dependence, but there was the possibility of A1 allelic association in severity of alcohol dependence. So this study implied that Korean alcohol dependence were influenced by extenal factor like severity of alcohol dependence rather than genetic factor. Therefore, these findings suggest that DRD2 allele play an important role of modifying gene in the process of alcohol dependence rather than the etiologic factor of alcohol dependence.
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KEYWORD
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Korean male alcohol dependence, Allele, Dopamine D2 receptor(DRD2), RFLP, Modifying gene
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